Anaerobic bacteria are part of normal human endogenous flora. The number of anaerobic bacteria progressively increased in the gastrointestinal tract to the colon where they are a thousand times more than aerobic bacteria. Some of these anaerobic bacteria are part of the infectious process, often based on an opportunistic event or after the anatomical and physiological perturbations infectious sites. Anaerobic bacteria pathogenicity is the most bacteria, but may be extended by the host-dependent factors (immunodeficiency), and bacterial environment. Bacteroides and Clostridium are two main anaerobic bacteria can be found in the flora of colic. Among the agents of clostridia,
Clostridium difficile is responsible for 15 to 25% of all cases of antibiotic-associated diarrhea and pseudomembranous colitis for most. This is a major enteropathogen bacteria isolated in nosocomial diarrhea in adults. Since 2003, highly pathogenic microorganism strains have appeared and the speed and severity of infections
C difficile has increased dramatically. Many factors of virulence, it seems that participate in the process
C difficile infection, but production of two toxins (TcdA and TcdB) plays an important role in the pathogenicity of the bacteria. Basic laboratory research activity focused on the mechanisms involved in initiation of transcription of genes encoding C difficile toxins in the regulation of their expression, as in the growth phase (phase transition) and in response to various environmental signals (sources of carbon, sulfur-containing amino acids) . Toxin secretion also studied. We also identify factors involved in colonization of the gastrointestinal tract buy strattera online from
C difficile (sporulyatsyy, adhesion, adaptation, multiplication) using
in vitro and in vivo comparative analysis of genes C. difficile
, when recovered from the infectious context (sterile mouse model). We currently produce genomic and transcriptomic comparative analysis of highly pathogenic microorganism strains. We expect to determine the factors responsible for the emergence of epidemic strains and hypervirulence as in the U.S. and Europe. .
